iRGD‐Targeted Physalis Mottle Virus Like Nanoparticles for Targeted Cancer Delivery

Nanomedicine provides a promising platform for the molecular treatment of disease. An ongoing challenge in nanomedicine is targeted delivery intravenously administered nanoparticles to particular tissues, which special interest cancer. Herein, conjugation iRGD peptides shown, specifically targets tumor neovasculature, surface Physalis mottle virus (PhMV)-like nanoparticles, leading rapid cellular uptake vitro and homing vivo. It then shown that iRGD-targeted PhMV loaded with chemotherapeutic doxorubicin shows increased potency murine flank xenograft model The results validate PhMV-like can be tumors through iRGD-peptide suggest iRGD-PhMV cargo tumors.